For those building a mono red deck, cards like Koth of the Hammer and Gauntlet of Might become much more attractive, as they provide a ton of mana in exchange for playing a lot of Mountains
The tri-colored identity might inhibit Bladecoil Serpents use, especially if the discard mode is the most appealing to you, but perhaps Nicol Bolas or Lord Xander, the Collector players might want a way to spread that hand-shredding love to everyone, not just target opponents
Where it gets truly strong, though, is playing those creatures that get arbitrarily large think Malignus, or Taurean Mauler and following up with instant speed Burn spells
If some attacks do get through your various fogs, having Maze of Ith and Kor Haven can spare you the brunt of most attacks
Ellie Rice, Magic game designer and member of the Commander Advisory Group, has a Commander deck that brings variety and fresh cards to every game
It also takes effect instantly and only costs one blue mana, which makes it an amazing way to shake up a game and one-up your opponent in a pinch