Cards that would make a player lose life, will work on Thanos, subtracting his loyalty by that amount (again, this acts effectively as his life)
This makes it useless after a board wipe, which is already a weakness for typal strategies
Or rather, they can do so, but it's counterintuitive and is likely to turn your commander from a decent threat that's hard to deal with to a game-ending wrecking ball that can dish out 21 commander damage in a single turn
Probably the best bet for white is the Forces of the Imperium Commander Deck, and as usual the vast armies of the Imperium act as cannon fodder for the Emperor
Artificer Class The only AFR class that didnt come from the main set, Artificer Class was printed in Battle for Baldurs Gate
However I just dont see where it fits currently in Standard