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In this model
Chemical Name: (S)-4'-((2
and its effectiveness depends on the active metabolite Cycloguanil (IC50=0
and increases activation of PKA
InChi: InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19
CJ-42794 Catalog No.:M20871-C In this modelCJ 42794 is a selective prostaglandin E receptor subtype 4(EP4) antagonist, inhibits [3H] PGE2 binding to the human EP4 receptor with a mean pKi of 8. 5, a binding affinity that was at least 200 fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). IC50 value: 8. 5 (pKi ) Target: EP4in vitro: CJ 042794 competitively inhibits PGE2 evoked elevations of intracellular cAMP levels in HEK293 cells
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