Handle by the edges only from the moment it leaves the pack if you intend to grade
It sees at least some play in most formats its legal in
If you draw a 2-drop later in the game, blitz it and cash in for a card
Whenever Slime Against Humanity is cast, it creates a 0/0 Ooze Creature Token, then puts +1/+1 counters on it equal to the number of other Oozes in your grave or Exile, plus the number of copies of Slime Against Humanity there too
While these two cards will be rotating out of Standard, it likely won't be a significant issue, as Bandai has already released better 2k counter Big Mom Pirates cards in the form of OP11-106-zeus-731 and ST20-003-charlotte-brulee
Some cards allow these ratios to change, some cards cover multiple groups and so forth