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Check out the Alchemy: Aetherdrift Spellbooks article for details on those cards.

Mono-Red was slightly unfavorable, particularly when you lose the die roll

Hero's Downfall This three-mana instant is next

For instance: Creatures (16) Lands (22) Spells (22) Sideboard Kotiranta knew his opponents would have a lot of sideboard hate for his fast black aggro deck, but Entomb + Reanimation spells + Vampiric Tutor to help set it up, let him transform into a combo deck that would surprise people with a quick Avatar of Woe or Phantom Nishoba, leaving them looking at the Shock in their hand in disbelief

It does come with a cost of losing life equal to the destroyed creature's toughness, however

You play them