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The only difference being that creatures, enchantments, and artifacts stay on the playing field whereas sorceries and instants are placed in your discard pile, also known as your graveyard , after casting their one-time effect
You can quite easily end up casting big flashy spells for just (3) mana, which, when youre also exiling that spell so they cant get it back, makes for quite a tempo swing
But in my experience it's very hard indeed to beat a resolved Humility if you A) can't remove it, or B) are planeswalker light
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The instant speed and unique wording of this effect makes it effective (if very costly) combo interaction in a lot of situations, since it will just sit in place like an invisible net and scoop up everything entering the battlefield for the rest of the current turn