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You want one that can get through your opponents defenses

If you are just playing the card straight up, its kind of a build your own Thoughtseize. That said, it was always particularly powerful that you could ensure your opponent doesnt have the card that can stop you, since even if you missed, it meant they didnt have that card

That cultural gravity translates directly and powerfully into the trading card market, where Mewtwo cards consistently rank among the most valuable and sought-after in the hobby

Consider cards that provide broad answers to common permanent types

Jadelight Spelunker Creatures with X in their mana cost are very flexible and are usually good early and late

Plus, they often get exclusive bundles or older sets that are harder to find elsewhere