They do nothing on their own, so only run them once your source-and-payoff core is solid
However, the life-gain focus opens up a lot of draw options
Sanctum Plowbeast, Jhessian Zombies, Pale Recluse, Igneous Pouncer and Valley Rannet aren't exactly Commander staples, but they're all two-color cards and they can each be cycled for one of two basic lands for the same cost of two mana
I would recommend getting three energy cards on Flaaffy, evolving it into Ampharos and then moving actually moving it into the active Pokemon spot and taking advantage of Ampharos's Ability
When you have efficient mana generation like Gaeas Cradle or Wirewood Channeler at your disposal, The Great Henge can allow you to play most of your deck in a single turn
Understanding the MTG card size is crucial for any Magic: The Gathering player or collector