They're difficult to remove, pack a punch, and have unique effects that synergize with your deck
However, a few (like Isochron Scepters ability) instruct you to copy a spell and cast the copy. These spells are cast and will count toward the number of spells cast that turn
Your best bet to pull it off is to play a commander like Selenia, Dark Angel that allows you to lose life on demand or have cards like Wall of Blood in play
While blinking your own creatures for value is the obvious first option with Phelia, it's important to note that Phelia can affect the opponent's board as well, opening up avenues to attack through problematic blockers
The Master, Transcendent is one of the most recognizable villains from Fallout, so of course it had to be here somewhere
I have built a fun Commander deck around them which you can find here where I built around the discard in the Command Zone to make a Self-Discard matters deck