They will not overwrite effects that modify power or toughness without setting it (whether from a static ability, counters, or a resolved spell or ability), nor will they overwrite effects that set power and toughness which come into existence after they resolve
But what more do you need than card draw and damage
Meanwhile Red has access to a lot of targeted artifact hate - Manic Vandal, Ingot Chewer, and Oxidda Scrapmelter - and White has primarily access to the enchantment hate - Dawnbringer Cleric, War Priest of Thune, Wispmare
Simply put, your opponent has to kill this creature or they have virtually no chance of winning, which is the simplest definition of a 10/10 card
This is generic great value, especially in Limited, and the in the mana cost lets this thing really shine in Commander
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