Elesclomol AY-600 Evidence for Involvement of the

Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis

MRZ) is a novel marine derived proteasome inhibitor which inhibits CT-L β5

Y06036 (Compound 6i) is a potent and selective inhibitor of BET with antitumor activity

20263-07-4

both β-catenin and panRas protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220

Elesclomol AY-600 Evidence for Involvement of theElesclomol, also known as STA 4783, is a HSP 90 Inhibitor, and is a small molecule bis(thio hydrazide amide) with oxidative stress induction, pro apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative