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241(4866):701-3
InChi: InChI=1S/C36H75N25O6/c37-19(7-1-13-51-31(39)40)26(63)58-21(9-3-15-53-33(43)44)28(65)60-23(11-5-17-55-35(47)48)30(67)61-24(12-6-18-56-36(49)50)29(66)59-22(10-4-16-54-34(45)46)27(64)57-20(25(38)62)8-2-14-52-32(41)42/h19-24H
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1
31)32)17-22-8-10-23(11-9-22)24-6-5-7-26(16-24)39(4
and glioblastoma cells
GSK J5 tan (medoxomil monopotassium) 241(4866):701-3The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.,. GSK J4 is a cell permeable prodrug which is modified by intracellular esterases to give GSK J1, an inhibitor of JMJD3. GSK J5 is a pyridine regio isomer of GSK J4. Like GSK J4, this isomer is cell permeable and hydrolyzed to a free base. 3 However, the free base is a
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