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K-Ras(G12C) inhibitor 6 Size:Contact [email protected] for quotation Oncogene (2008) 27

SKU: 70751766788

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Description

Oncogene (2008) 27

K-Ras(G12C) inhibitor 6 Size:Contact [email protected] for quotation Oncogene (2008) 27K Ras (G12C) inhibitor 6 is an allosterical inhibitor of oncogenic mutation K Ras G12C . K Ras (G12C) inhibitor 6 is a cysteine reactive small molecule. It irreversibly binds to the G12C mutantion of GTPase K Ras but not the wild type K Ras with the relative potency value of 4. 2. The binding pocket of K Ras for K Ras (G12C) inhibitor 6 is a new allosteric pocket, S IIP. Binding of this pocket results in a change of the relative nucleotide affinity of

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