Pay in 4 interest-free payments of $25.00 Learn more
Ships within 48 hours · Estimated delivery Jul 31 - Aug 5
AP521 at 3 mg/kg tends to increase the extracellular 5-HT level
SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs
with a Ki of 3 nM
CAS Number: 188260-50-6
InChiKey: ZTQSADJAYQOCDD-HUGMCNGHSA-N
Tyk2-IN-7 ogladine AP521 at 3 mg/kg tendsTyk2 IN 7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki. app of 0. 00053 M and 0. 00007 M, respectively. Tyk2 IN 7 (Compound 48) provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2 JAK1 JAK2 kinase domain. Tyk2 IN 7 (Compound 48) provides robust inhibition in a mouse IL 12 induced IFN pharmacodynamic model as well as efficacy in an IL 23 and IL 12 dependent mouse colitis