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InChiKey: IUKLSMSEHKDIIP-BZMYINFQSA-N
Meys which possesses anti-cancer activity
Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit
delafloxacin MICs and MPCs remain low and a fitness cost can be observed
COX-2 and CRP expression is due to a dose-dependent inhibition of phosphorylation and degradation of I-κB
EN6 HIBO InChiKey: IUKLSMSEHKDIIP-BZMYINFQSA-NEN6 is a small molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v ATPase). EN6 mediated ATP6V1A modification decouples the v ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP 43 aggregates, a causative agent in frontotemporal dementia, in a lysosome dependent manner.
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