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Darbufelone is a noncompetitive inhibitor of PGHS-2 (Ki=10±5 μM)
The inhibitor is significantly less active towards other kinases
because DEL-22379 displays similar dimerization- and cytoplasmic signaling-inhibitory dose responses (IC50 of 150-400 nM) regardless of the genotype
GS-7977 D6
thiazole-4-acetic acid derivatives
Illudin S LN024 Darbufelone is a noncompetitive inhibitorIlludin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1 S phase interface of the cell cycle in human leukemia cells. Product information CAS Number: 1149 99 1 Molecular Weight: 264. 32 Formula: C15H20O4 Chemical Name: (2'S,3'R,6'R) 3',6' dihydroxy 2' (hydroxymethyl) 2',4',6' trimethyl 2',3',6',7' tetrahydrospiro[cyclopropane 1,5' inden] 7'
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