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Smiles: O=C(NC1=CC(Cl)=CC=C1)C1=CC=CC=N1
Chemical Name: 4-[5-(pyridin-4-yl)-1H-1
PAR4 antagonists is potential useful for the development of tools such as radioligands and PET tracers that are not currently available to the field for this target
Raltitrexed is a quinazoline folate analogue with antineoplastic activity
It was discovered in 1966 by M
Valproic acid - CAS# 99-66-1 Size:Solid 2 mg Smiles: O=C(NC1=CC(Cl)=CC=C1)C1=CC=CC=N1AI 10 49 is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBF SMMHC
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