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COH29 (RNR Inhibitor COH29) overcome hydroxyurea and gemcitabine resistance in cancer cells
2-b]pyrazine-2
which is similar to its IC50 for target inhibition
Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs
InChiKey: HKIKAXXIWJHWLY-ZIIYPAMZSA-N
SCH772984 TFA PAB-MMAD COH29 (RNR Inhibitor COH29) overcomeSCH772984 TFA Product information Molecular Weight: 701. 70 Formula: C35H34F3N9O4 Chemical Name: (3S) 1 (2 oxo 2 {4 [4 (pyrimidin 2 yl)phenyl]piperazin 1 yl}ethyl) N [3 (pyridin 4 yl) 2H indazol 5 yl]pyrrolidine 3 carboxamide; trifluoroacetic acid Smiles: OC(=O)C(F)(F)F. O=C(NC1=CC2=C(NN=C2C=C1)C1C=CN=CC=1)[C@@H]1CN(CC(=O)N2CCN(CC2)C2C=CC(=CC=2)C2N=CC=CN=2)CC1 InChiKey: MYDYZQIKLTVYFO UQIIZPHYSA N InChi: InChI=1S C33H33N9O2. C2HF3O2 c43 30(42 18 16