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Pixantrone (dimaleate) Catalog No.:M9764-10 and it causes selective ubiquitination

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Description

and it causes selective ubiquitination and degradation of two lymphoid transcription factors

(2015) Cancer Cell

Lersivirine is able to inhibit HIV-1 virus replication in MT-2 cells infected with wt NL4-3

Smiles: C[N@@+]1(CCC2=CC(OC)=C(C=C2[C@H]1CC1=CC(OC)=C(C=C1)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N@@+]1(C)CCC2=CC(OC)=C(C=C2[C@H]1CC1=CC(OC)=C(C=C1)OC)OC

PubMed Central PMCID: PMC4264672

Pixantrone (dimaleate) Catalog No.:M9764-10 and it causes selective ubiquitinationPixantrone is a synthetic, noncardiotoxic aza anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Pixantrone is a potentially more effective, less cardiotoxic alternative to doxorubicin for patients with aggressive non Hodgkin lymphoma (aNHL). Product information CAS Number:

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