BMS-1166 hydrochloride Catalog No.:M14627-2 2013 May 24

2013 May 24

PF-06282999 is moderately bound to plasma proteins across preclinical species and humans

Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 20nM)

53(3):1086-97

InChiKey: BRZGXSNAXRPPFI-UHFFFAOYSA-N

BMS-1166 hydrochloride Catalog No.:M14627-2 2013 May 24BMS 1166 hydrochloride is a potent PD 1 PD L1 immune checkpoint inhibitor. BMS 1166 hydrochloride induces dimerization of PD L1 and blocks its interaction with PD 1, with an IC50 of 1. 4 nM. BMS 1166 hydrochloride antagonizes the inhibitory effect of PD 1 PD L1 immune checkpoint on T cell activation. Product information CAS Number: 2113650 05 6 Molecular Weight: 677. 57 Formula: C36H34Cl2N2O7 Chemical Name: (2R,4R) 1 ({5 chloro 2 [(3