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BI 1482694
1 amide-PEG4-amine
Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes
It inhibits platelet aggregation and is a direct arterial vasodilator
Chemical Name: 3-[(3R
Leucovorin (Calcium) tetrahydrofolate BI 1482694Leucovorin calcium is a n active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of