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Catalytic in vivo protein knockdown by small-molecule PROTACs
114(16):3439-47
2 substrates of this enzyme
Chemical Name: Benzoic acid
PubMed Central PMCID: PMC3701049
Ro 25-6981 maleate Catalog No.:M9288-2 Catalytic in vivo protein knockdownRo 25 6981 is a highly potent and selective blocker of N methyl D aspartate receptors containing the NR2B subunit. Ro 25 6981 inhibited 3H MK 801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0. 003 microM and 149 microM for high (about 60%) and low affinity sites, respectively. NMDA receptor subtypes expressed in Xenopus oocytes were blocked with IC50 values of 0. 009 microM and 52 microM for the subunit combinations
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