Tebanicline hydrochloride Size:Contact [email protected] for quotation InChi: InChI=1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4

InChi: InChI=1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4

is a pyrrolidinone-type cognition enhancer that has been clinically used in the treatment of behavioral and psychological symptoms of dementia following stroke and in Alzheimer's disease

CAS Number: 2064292-12-0

and causes a 50-day survival rate of 60% and 50%

The low-affinity site accounts for the residual 75% of binding (IC50) 790 nM and represents binding to the R1a sites

Tebanicline hydrochloride Size:Contact [email protected] for quotation InChi: InChI=1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to 42 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a novel, potent cholinergic nAChR ligand with analgesic properties that shows preferential selectivity for neuronal nAChRs. It inhibits the binding of cytisine to 42 neuronal nAChRs with a Ki of 37 pM. Functionally, tebanicline is an agonist.