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Constituents with DNA topoisomerases I and II inhibitory activity and cytotoxicity from the roots of Rubia cordifolia
Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor
Smiles: OC1(CN(C1)C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F)[C@@H]1CCCCN1
releases no more β-hexosaminidase compared with cells that are not exposed to ionomycin (4%)
6 nM for hα4β4
Varlitinib bic acid 2-phosphate Constituents with DNA topoisomerases IVarlitinib (ASLAN001) is a potent, reversible, small molecule pan EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively. Product information CAS Number: 845272 21 1 Molecular Weight: 466. 94 Formula: C22H19ClN6O2S Chemical Name: N4 {3 chloro 4 [(1,3 thiazol 2 yl)methoxy]phenyl} N6 (4 methyl 4,5 dihydro 1,3 oxazol 2 yl)quinazoline 4,6 diamine Smiles: CC1COC(NC2C=CC3N=CN=C(NC4=CC(Cl)=C(C=C4)OCC4=NC=CS4)C=3C=2)=N1 InChiKey:
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