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PubMed PMID: 20629316
Smiles: CN(C)CC(=O)NC[C@H](CC1C=CC(=CC=1)C1=CN2C=CC=C([C@H](C)O)C2=N1)NC(=O)C1=CC(Cl)=C(C=C1)OC(C)C
Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
InChiKey: CYYZQGUDHAKBIQ-UHFFFAOYSA-N
Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3
BAY-985 Catalog No.:M7451-2 PubMed PMID: 20629316BAY 985 is a potent and highly selective TBK1 IKK inhibitor. BAY 985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKK(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK MEL 2 cells (IC50 = 900 nM). Product information CAS Number: 2409479 29 2 Molecular Weight: 553. 58 Formula: C27H30F3N9O Chemical Name: 1 (4 {(1R) 1 [2 ({6 [6
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