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Epub 2015 Aug 5
InChiKey: SJVQHLPISAIATJ-ZDUSSCGKSA-N
C4H11N/c7-4-1-2-5(8)6(3-4)12(9
DY131 could potentiate the ERRgamma-induced growth inhibition in LNCaP-ERRgamma and DU145-ERRgamma cells in a dose-dependent manner
KG-1 and GDM-1 with IC50 values of 10 nM
(R)-CR8 - CAS# 294646-77-8 Size:2mg solid Epub 2015 Aug 5(R) CR8 (CR8), a second generation analog of Roscovitine, is a potent CDK1 2 5 7 9 inhibitor. (R) CR8 inhibits CDK1 cyclin B (IC50=0. 09 M), CDK2 cyclin A (0. 072 M), CDK2 cyclin E (0. 041 M), CDK5 p25 (0. 11 M), CDK7 cyclin H (1. 1 M), CDK9 cyclin T (0. 18 M) and CK1 (0. 4 M). (R) CR8 induces apoptosis and has neuroprotective effect[1][2]. (R) CR8 acts as a molecular glue degrader that depletes cyclin K. Product information CAS Number: 294646 77 8
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