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potent and cell-permeable inhibitor of p38 MAP kinase
03 μg/mL to 0
Jpn J Pharmacol
PubMed Central PMCID: PMC4397928
InChiKey: WKRWUYKLUMMAKG-WYGBAUISSA-L
LY315920(Varespladib) endizoate potent and cell-permeable inhibitor ofVarespladib, aslo known as LY315920, is a secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 750 nM for a range of sPLA2 isoforms). Varespladib reduces atherosclerosis and aneurysm formation in ApoE mice and in guinea pigs. Varespladib significantly reduces the post ACS inflammatory response in those with and without diabetes. Varespladib may be potentially useful for treatment of coronary artery disease. Product information CAS Number: 172732 68
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