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multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR)
74(1):3-14
14-33)48-30-26(39)25(38)23(36)21(45-30)13-44-29(40)16-5-7-17(34)8-6-16/h4-11
resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells
PF-04457845 completely inhibits FAAH in human and mouse membrane proteomes at both 10 and 100 μM with no off targets
5'-O-TBDMS-dA 430ropargyl-PEG1-acid multitargeted tyrosine kinase inhibitor (TKI)5' O TBDMS dA is a modified nucleoside and can be used to synthesize DNA or RNA. Product information CAS Number: 51549 30 5 Molecular Weight: 365. 50 Formula: C16H27N5O3Si Chemical Name: (2R,3S,5R) 5 (6 amino 9H purin 9 yl) 2 {[(tert butyldimethylsilyl)oxy]methyl}oxolan 3 ol Smiles: CC(C)(C)[Si](C)(C)OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C(N)N=CN=C12 InChiKey: HGLRBQHXIBHZTD QJPTWQEYSA N InChi: InChI=1S C16H27N5O3Si c1 16(2,3)25(4,5)23 7 11 10(22)6 12(24