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CAS Number: 5428-80-8
It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3-kinases in the signal transduction pathways involved in cell migration
Formula: C27H28N2O3
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor
but not ALK4
AI-10-49 - CAS# 1256094-72-0 60268 CAS Number: 5428-80-8AI 10 49, CAS No. 1256094 72 0, is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the
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