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with an IC50 of < 1 nM
CB-103 blocks tumor growth of GSI-resistant cancers
An Orally Available
VER-50589 inhibits Hsp90 with an IC50 value of 21 nM
Biggadike K
Sophocarpine monohydrate 260omalidomide-C4-NH2 hydrochloride with an IC50 of <Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti virus, anti tumor, anti inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down regulation of cell survival PI3K AKT signaling