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PubMed PMID: 22284361
inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity
[Epub ahead of print] PubMed PMID: 20502937
Arrendale RF
orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
Ku-55933 - CAS# 587871-26-9 0193 PubMed PMID: 22284361KU 55933, CAS No. 587871 26 9, is an ATM inhibitor. KU 55933 blocks the phosphorylation of Akt induced by insulin and insulin like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU 55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU 55933 treatment during
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