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Chemical Name: 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamide
suggesting that DR5 mediates reduction of IκBα and p-Akt induced by GGTI298/TRAIL
RA190 administration profoundly reduced growth of MM and ovarian cancer xenografts
2018 Oct 31
Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors
Salinomycin - CAS# 53003-10-4 055 Chemical Name: 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)benzamideSalinomycin, CAS No. 53003 10 4, is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti cancer drug paclitaxel. The mechanism of action by which salinomycin kills cancer stem cells specifically remains unknown, but is thought to be due