Doxazosin rasugrel (Maleic acid) Exposures (AUC) increases in a

Exposures (AUC) increases in a less than dose-proportional manner from 23 μM•h at 5 mg/kg to 362 μM•h at 500 mg/kg

Formula: C13H12F2N6O

3-a]pyridine

tartrate-resistant acid phosphatase (TRAP)

Smiles: COC1C=CC(CN2C=CC3=CC=C(C=C23)C(=O)NO)=CC=1

Doxazosin rasugrel (Maleic acid) Exposures (AUC) increases in aDoxazosin is an 1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the 1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha 1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha 1c adrenoceptor, the predominant functional type in