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The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus
MGCD0103 binds to and inhibits Class 1 isoforms of HDAC
Chemical Name: 4-(7-{[(3S)-3-Amino-1-pyrrolidinyl]carbonyl}-1-ethyl-1H-imidazo[4
217 and 451 nM for c-Fms
Ingenol Mebutate - CAS# 75567-37-2 Catalog No.:M6794-2 The histone deacetylase inhibitor MS-275Ingenol Mebutate, CAS No. 75567 37 2, also known as ingenol 3 angelate, is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. Ingenol Mebutate was approved for the topical treatment of actinic keratosis. Ingenol mebutate has also been found to be useful for reactivating latent HIV virus in cells taken from individuals who have tested negative for signs of the disease following extended courses of anti retroviral