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Ships within 48 hours · Estimated delivery Aug 10 - Aug 15
including DOT1
1190378-57-4
Formula: C29H43NO4S
Chemical Name: 3-(2-Naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one
2 nM) in inhibiting isoproterenol-induced cAMP production in HEK-293 cells
PI-3065 Catalog No.:M8668-10 including DOT1PI3065 is a p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) inhibitor. Inhibitors against the p110 isoform of phosphoinositide 3 OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110 is primarily expressed in leukocytes, drugs against p110 have not been considered for the treatment of solid tumours. p110 inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression.
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