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Fasudil via i
Formula: C22H29N7O
5S)-2-(hydroxymethyl)-1
MLN-9708 inhibits the invasion ability of MG-63 and Saos-2 cells and decreases both the expression and secretion levels of MMP2/9
PubMed PMID: 23820456
CCG-1423 Catalog No.:M9362-10 Fasudil via iCCG 1423 is a small molecule inhibitor of RhoA transcriptional signaling. CCG 1423 displays activity in several in vitro cancer cell functional assays. CCG 1423 potently (<1 mumol L) inhibits lysophosphatidic acid induced DNA synthesis in PC 3 prostate cancer cells, and whereas it inhibits the growth of RhoC overexpressing melanoma lines (A375M2 and SK Mel 147) at nanomolar concentrations, it is less active on related lines (A375 and SK Mel 28) that