IL-17A inhibitor 1 Size:Contact [email protected] for quotation InChi: InChI=1S/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15

InChi: InChI=1S/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15

Chemical Name: [4-[[(2S)-2-[[(2S)-2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R

but without affecting cortisol levels

de Lecea L

CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties

IL-17A inhibitor 1 Size:Contact [email protected] for quotation InChi: InChI=1S/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15IL 17A inhibitor 1 (example 24) is a IL 17A inhibitor, with IC50 values of <9. 45 nM and 9. 3 nM in alphalisa assay and HT 29 cells. Product information CAS Number: 2452464 73 0 Molecular Weight: 586. 51 Formula: C24H27F5N8O4 Chemical Name: N [(S) (4, 4 difluorocyclohexyl)({7 [(1S) 2 methoxy 1 [(4S) 2 oxo 4 (trifluoromethyl)imidazolidin 1 yl]ethyl]imidazo[1, 2 b]pyridazin 2 yl})methyl] 4 methyl 1, 2, 5 oxadiazole 3 carboxamide Smiles: