![RI-1 - CAS# 415713-60-9 n (1-7) 7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10195_1621561486.gif?v=1742876866)
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7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4
1393477-72-9
The highly polar carboxylate group of GSK-J1 restricts its cellular permeability
4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1
also known as 10-DAB or 10-DAB III
RI-1 - CAS# 415713-60-9 n (1-7) 7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4RI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into
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