R-GNE-140 - CAS# 2003234-63-5 size:2mg solid 7(5):531-6

7(5):531-6

Molecular Weight: 575

It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM)

compound 1

Formula: C21H22Cl2FN5O

R-GNE-140 - CAS# 2003234-63-5 size:2mg solid 7(5):531-6R GNE 140, CAS No. 2003234 63 5, a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB. In MIA PaCa 2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE 140, but could be resensitized to