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GSK269962A suppressed IL-6 mRNA transcription and reduced LPS-induced IL-6 and TNF-α protein production in macrophages
It is derived from the actinobacterium Streptomyces griseus
InChi: InChI=1S/C55H57ClFN7O8S/c1-34-50(73-33-61-34)38-10-8-35(9-11-38)28-58-53(67)47-27-42(65)29-64(47)54(68)51(55(2
The levels of inflammatory cytokines IL-1
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PF-431396 Catalog No.:M10987-10 GSK269962A suppressed IL-6 mRNA transcriptionPF 431396 is a potent and selective focal adhesion kinase (FAK) and proline rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Product information CAS Number: 717906 29 1 Molecular Weight: 506. 50 Formula: C22H21F3N6O3S Chemical Name: N methyl N {2 [({2 [(2 oxo 2,3 dihydro 1H indol 5 yl)amino] 5 (trifluoromethyl)pyrimidin 4 yl}amino)methyl]phenyl}methanesulfonamide Smiles:
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