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Smiles: CC1=CC=NC(C(C)C)=C1N1C2=NC(C3=C(O)C=CC=C3F)=C(F)C=C2C(=NC1=O)N1CCN(CC1C)C(=O)C=C
1 channels positive modulator
with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
Anatabine inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP)
conversely
PF-06409577 123icafungin Sodium Smiles: CC1=CC=NC(C(C)C)=C1N1C2=NC(C3=C(O)C=CC=C3F)=C(F)C=C2C(=NC1=O)N1CCN(CC1C)C(=O)C=CPF 06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for 111 in the TR FRET assay and it shows no detectable inhibition of hERG in a patch clamp assay (100 M) and was not an inhibitor (IC50 > 100 M) of the microsomal activities of major human cytochrome P450 isoforms. Product information CAS Number: 1467057 23 3 Molecular Weight: 341. 79 Formula: C19H16ClNO3 Chemical Name: 6 chloro 5 [4 (1 hydroxycyclobutyl)phenyl] 1H indole 3
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