TAK-960 monohydrochloride 9-4603 heNOS and hnNOS

heNOS and hnNOS

Smiles: OC1C=CC(=CC=1)[C@@H]1CC(=O)C2=CC=C(C=C2O1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@](O)(CO)[C@H]1O

Smiles: C/C=C/C[C@@H](C)C(=O)[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C

Chemical Name: 1-{2-oxo-2-[3'-(trifluoromethyl)-[1

740 Y-P (30 μM

TAK-960 monohydrochloride 9-4603 heNOS and hnNOSTAK 960 monohydrochloride is an orally available, selective inhibitor of polo like kinase 1 (PLK1), with an IC50 of 0. 8 nM. TAK 960 monohydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16. 9 and 50. 2 nM, respectively. TAK 960 monohydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts. Product information CAS Number: 2108449 45 0