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Probe Reports from the NIH Molecular Libraries Program
342(6161):979-83
making it a good drug candidate for cancer therapy
SAR407899 (3 μM) completely blocks thrombin-induced shrinkage of human umbilical vein endothelial cells (HUVECs) and stress fiber formation
ISRIB-treated mice display significant enhancement in spatial and fear-associated learning
DY-131 - CAS# 95167-41-2 60200 Probe Reports from the NIHDY131, also known as GSK 9089, CAS No. 95167 41 2, is a novel selective agonist at estrogen related receptors ERR and ERR. DY131 could potentiate the ERRgamma induced growth inhibition in LNCaP ERRgamma and DU145 ERRgamma cells in a dose dependent manner. ERRgamma may perform an antiproliferative or tumor suppressing function in prostate cancer cells. ERRgamma could be a novel therapeutic target for prostate cancer treatment. Product information CAS
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