IU1 - Proteasome USP14 Inhibitor. CAS# 314245-33-5 size:10mg solid Its affinity to SETD8 was

Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies

EPZ015666 was used at 5 µM final concentration in various in vitro assays

TAME was used at 50-200 µM final concentration in various in vitro assays

(2013) Cell 153(7):1552-66

Formula: C19H18BrN3O

IU1 - Proteasome USP14 Inhibitor. CAS# 314245-33-5 size:10mg solid Its affinity to SETD8 wasIU1, CAS No. 314245 33 5, is a cell permeable, reversible and selective inhibitor of human USP14 with an IC50 of 4. 7 M. It selectively stimulates ubiquitin dependent protein degradation in vitro at 34 M and in MEF cells at 50 M. At 75 M, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress. Usp14 inhibition accelerated the degradation of oxidized proteins and enhanced resistance to