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(2008) Biochem J
a PDGFR inhibitor
or 75 mg/kg causes tumor growth inhibition with TGI of 19%
(1998) Bioorg Med Chem Lett
AK-7 was used at 10-25 µM in vitro and in cellular assays
CHIR99021 - GSK3β Inhibitor. CAS# 252917-06-9 Catalog No.:M60002-25S (2008) Biochem JCHIR99021, CAS No. 252917 06 9, is the most widely used, potent and selective inhibitor of glycogen synthase kinase 3 (GSK3) with an IC50 ~7 nM. It can effectively activate Wnt signaling pathway in various cellular systems. CHIR99021 has been shown to enhance the reprogramming of murine and human somatic cells into iPSCs, potently promote expansion of embryonic stem cells and tissue specific adult stem cells (such as hematopoietic stem and progenitor