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metabolite of AZD9291
Chemical Name: 1-(1-(4-fluorophenyl)-2
Aticaprant (CERC-501) alleviates the nicotine withdrawal syndrome
3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice
Smiles: NC1N=C(COC(=O)C2C=CC(=CC=2)[N+]([O-])=O)N=C(NC2C=CC=CC=2)N=1
Furamidine dihydrochloride - PRMT1 Inhibitor. CAS# 55368-40-6 0113 metabolite of AZD9291Furamidine, CAS No. 55368 40 6, is a potent, selective and cell permeable Protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9. 4 M. It has >10 fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 M respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell