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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39
AG-1517 inhibits EGF-stimulated receptor autophosphorylation in A431 human epidermoid carcinoma cells
107(10):1499-1505
and spontaneous TNFα production by synovial explants from RA patients
ML311 10402 MTH1 inhibition eradicates cancer byML311 is a potent and selective inhibitor of the Mcl 1 Bim interaction. Product information CAS Number: 315698 17 0 Molecular Weight: 415. 45 Formula: C23H24F3N3O Chemical Name: 7 [(4 ethylpiperazin 1 yl)[4 (trifluoromethyl)phenyl]methyl]quinolin 8 ol Smiles: CCN1CCN(CC1)C(C1=CC=C2C=CC=NC2=C1O)C1C=CC(=CC=1)C(F)(F)F InChiKey: NGAPBLRRJSKIRT UHFFFAOYSA N InChi: InChI=1S C23H24F3N3O c1 2 28 12 14 29(15 13 28)21(17 5 8 18(9 6 17)23(24,25)26)19 10 7 16 4 3
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