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3*1H2/t33-
also known as ASP2151
GSK429286A has 61% oral bioavailability in male Sprague-Dawley rats
InChiKey: NOJNFULGOQGBKB-UHFFFAOYSA-M
InChi: InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H
SGX-523 - CAS# 1022150-57-7 Size:Solid 10 mg 3*1H2/t33-SGX523 is a novel, ATP competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol L and is >1,000 fold selective versus the >200 fold selectivity of other protein kinases tested in biochemical assays. Crystallographic study revealed that SGX523 stabilizes MET in a unique inactive conformation that is inaccessible to other protein kinases, suggesting an explanation for the
US$ 29.00
US$ 3125.00