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Chemical Name: N-(6-((2S
independent of either inhibition of the p53-p21 pathway or activation of the Wnt-β-catenin signaling
21-11+/t26-/m0/s1
also inhibits HDAC1 with an IC50 of 9 nM
EMCS crosslinking reagent's NHS ester and maleimide reactive groups react with amino and sulfhydryl moieties
RepSox - TGF-β Type I Receptor ALK5 Inhibitor. CAS# 446859-33-2 0273 Chemical Name: N-(6-((2SRepSox (E 616452 or SJN 2511), CAS No. 446859 33 2, is a highly potent, selective inhibitor of the TGF type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. It has good selectivity for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 M). RepSox is able to successfully replace Sox2 in reprogramming by inhibiting transforming growth factor (Tgf ) signaling, which in