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Paediatr Drugs
is a n orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity
is a selective FTO inhibitor
Formula: C52H60F2N8O7
C75 FASN inhibitor
CHIR-98014 - CAS# 252935-94-7 Size:Solid 2 mg Paediatr DrugsCHIR98014, also known as CT 98024, is a reversible, cell permeable inhibitor of GSK3 and GSK3 (IC50 = 0. 65 and 0. 58 nM, respectively). It is inactive against a series of other serine threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also